numbers game

15-20% of all pregnancies will end in miscarriage. Of those 15-20% of women, 3-5% will experience multiple miscarriages.

"The reported incidence of preterm premature rupture of membranes ranges between 1% and 2% of all pregnancies."

"Recurrent preterm premature rupture of membranes occurred in 39 of 121 patients, for a rate of 32.2% (95% confidence interval, 23.9 +/- 40.5)." ..."We conclude that patients with preterm premature rupture of membranes should be counseled regarding the significant risk of recurrence and need to have close follow-up in their subsequent pregnancies."

Spontaneous PPROM vs Iatrogenic PPROM:
Pregnancy after iatrogenic PPROM had a better prognosis than after spontaneous PPROM. Intensive management with corticosteroids and antibiotics appeared to be helpful. Neonatal survival in spontaneous PPROM before 24 weeks remained very poor and discussing pregnancy termination in these cases seems legitimate.

There is currently no treatment capable of sealing the fetal membranes in patients with spontaneous PPROM. Spontaneous PPROM lesions are hard-to-heal wounds, like chronic wounds, which complicates repair.